FlamLeve is your natural anti-inflammatory for everyday use.

FlamLeve reduces inflammation and pain and protects your body from inflammatory damage. FlamLeve is ideally used to relieve mild pain, discomfort and stiffness resulting from muscle injury and inflammation, as well as an assistive therapy for acute and chronic inflammatory conditions of the organs.

• What does FlamLeve do?

  FlamLeve reduces inflammation and pain and protects your body from inflammatory damage. FlamLeve is ideally used to relieve mild pain, discomfort and stiffness resulting from muscle injury and inflammation, as well as an assistive therapy for acute and chronic inflammatory conditions of the organs.

  How does the ingredients in FlamLeve work?

  GreenFlam blend (contains curcumin & piperine extracts)

  Curcumin is an organic compound sourced from a flowering plant (Curcuma longa). The dried and powdered root belongs to the ginger family and is extensively used in Eastern cuisine as the traditional spice turmeric.

  Medicinal uses

  Curcumin has also been used in Eastern traditional medicine to treat various inflammatory conditions including several forms of arthritis, inflammatory bowel disorders and chronic lung conditions. It contains several bioactive molecules that possess many health benefits, including anti-inflammatory, antioxidant and pain-relieving properties.
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  As a spice in its natural form, curcumin is poorly absorbed into the body and rapidly passes through the intestines, thereby restricting its therapeutic use. Over the last 10 years, however, the introduction of modern pharmaceutical drug-delivery technologies has solved this limitation and expanded its benefits to several other organ systems besides the intestines.

  The highly concentrated curcumin extract contained within FlamLeve, for example, demonstrates a 5-fold (500 times) increase in potency over curcumin in its natural state as turmeric. By pairing this potent concentrate with piperine, a natural molecule derived from black pepper, its bioavailability is further improved by a factor of 20. In total, this unique feature makes GreenFlam thousands of times more effective than the spice in its raw form.

  Boswellia bark extract

  Boswellia serrata is a small to medium sized tree that lives in the arid and mountainous regions of India and the Arabian Peninsula. Indian frankincense is derived from the bark sap of the tree. This sap builds up as a sticky resin in gashes cut into the bark of the tree where it is harvested. Due to its distinctive aroma, it is widely used in the manufacture of incense and perfumes.

  Medicinal uses

  Boswellia bark extract has been used for medicinal purposes as a natural anti-inflammatory and pain-relieving agent in Chinese and Indian Traditional medicine for centuries. Research has found that the bark extract contains a range of therapeutic molecules called boswellic acids which protect against inflammatory conditions in several bodily tissues, organs and joints.
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  Clinical trials have validated the efficacy of Boswellia bark extract against osteoarthritis, inflammatory pain, certain skin disorders and gingivitis. Research has also demonstrated benefits in other bodily tissues such neuro-inflammation triggered by brain injury in stroke patients,  chronic kidney disease (CKD), inflammatory prostatitis in men and fibrocystic breast changes in women.

  How does FlamLeve work?

  Convincing evidence from extensive medical research indicates that the damage caused by acute inflammation often plays a dominant role in the development of several chronic diseases. These include arthritis, obesity, diabetes, cardiovascular diseases, neurological diseases and cancer.

  Several inflammatory molecules released by the immune system are also implicated in sustaining long-term, low level inflammation, a process directly linked to many chronic diseases.  Suppressing the inflammatory pathways responsible has therefore become a modern therapeutic strategy for the prevention and alleviation of disease.
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  In depth research on the molecular effects of several of the medicinal compounds present in both curcumin and Boswellia bark extract has indicated that these plants demonstrate multimodal molecular activity via several biological targets involved in the activation and acceleration of inflammation. This includes the inhibition of NF-κβ based pro-inflammatory activation and a reduction in the levels the pain producing cytokine TNF-alpha. Other molecular targets include the enzymatic activation of the matrix metallopeptidases (MMPs), cathepsins (CatG) and prostaglandin E2 synthase-1 (mPGES-1), all powerful promotors of progressive tissue destruction.

• How can FlamLeve assist me?

  FlamLeve contains a unique blend of herbal extracts that complement each other and work together against inflammation. The combined effects help to alleviate the pain and discomfort caused by inflammation and offer protection against inflammatory damage to tissues, joints and organs.

  FlamLeve can be used for:

  Assistance during acute inflammatory conditions and injuries

  • For acute inflammation as a result of injuries, sprains and strains (including sports injuries)
  • For muscle inflammation and stiffness (including the effects of intensive exercise)
  • For relief from pain and discomfort caused by inflammation

  As a long-term protective supplement for chronic inflammatory disorders

  • For arthritic pain and inflammation caused by osteoarthritis and gout
  • For soft tissue inflammation, including of breasts tissue and the prostate gland (under the supervision of a doctor)
  • As a supplement for certain inflammatory lung disorders such as asthma and chronic obstructive airway disease (in conjunction with prescription medication)
  • To help protect your joints and internal organs from long-term inflammatory damage

• What does FlamLeve contain?

  FlamLeve contains a unique, proprietary, blend of herbal extracts that work together to help alleviate discomfort and pain caused by inflammation and prevent inflammatory damage to tissues and organs. These ingredients are:

  • GreenFlam – a propriety blend of curcumin at a 95% potency, extracted from the spice turmeric. In the GreenFlam formula, the curcumin is paired with piperine, a molecule extracted from black pepper. This unique combination enhances curcumin’s absorption by a factor of twenty (or up to 2000 times).
  • Boswellia bark extract – in a concentrated form containing 65% boswellic acids, derived from the Indian Frankincense tree.

  One tablet contains:

  Ingredients
  GreenFlam Curcumin (95%, as turmeric extract) Piperine (as black pepper extract)	250 mg 20 mg
  Boswellic acids (65%, as Boswellia serrata extract)	325 mg

   

  See below for a scientific overview of each of these ingredients.

• Who may benefit from taking FlamLeve?

  FlamLeve can be used by anyone who is experiencing discomfort caused by inflammation, whether it is chronic or acute. This includes anyone suffering sports injuries, muscle strains or sprains as well as persons with more long term inflammatory disorders. FlamLeve is also an ideal assistive therapy for anyone dealing with chronic inflammatory conditions that may affect tissues or organs in the body.

• What is the usual dosage?

  Take 1-3 tablets per day as needed.

• Who should not use FlamLeve?

  You should not take FlamLeve if you are hypersensitive or allergic to any of the active or inactive ingredients of FlamLeve, are pregnant, breastfeeding or are under the age of 12 years old.

• What are the side effects of FlamLeve?

  Extensive clinical trials in human subjects have demonstrated that the natural ingredients contained in FlamLeve have a gentle anti-inflammatory effect with a low side-effect profile. These pose a low health risk, especially when compared to pharmaceutical anti-inflammatory and painkilling drugs. Mild gastrointestinal irritation may occur.  To avoid this potential effect, FlamLeve should always be taken with food.

• Where can FlamLeve be obtained?

  • Shop Online
  • South Africa: At any pharmacy. No prescription is required.
  • Namibia: At any pharmacy. No prescription is required.

• Can FlamLeve be used in combination with prescription medication?

  Yes, FlamLeve may be taken with most prescription drugs, including Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and pain killers. Care should also be taken if you are taking Central Nervous System (CNS) depressants, anti-diabetic or blood thinning medications as FlamLeve may enhance their effects. It is always important to inform your doctor of any supplements you are taking, especially if you are already being treated for another condition.

• Scientific references

  Curcumin Curcumin: a modulator of inflammatory signaling pathways in the immune system. Kahkhaie KR, Mirhosseini A, Aliabadi A, Mohammadi A, Mousavi MJ, Haftcheshmeh SM, Sathyapalan T, Sahebkar A. Inflammopharmacology. 2019 Oct;27(5):885-900. doi: 10.1007/s10787-019-00607-3. Epub 2019 May 28. Review. Erratum in: Inflammopharmacology. 2019 Aug 19;:.

  Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: A systematic review and meta-analysis of randomized controlled trials. White CM, Pasupuleti V, Roman YM, Li Y, Hernandez AV. Pharmacol Res. 2019 Aug;146:104280. doi: 10.1016/j.phrs.2019.104280. Epub 2019 May 20. Review.

  Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro. Zhu T, Chen Z, Chen G, Wang D, Tang S, Deng H, Wang J, Li S, Lan J, Tong J, Li H, Deng X, Zhang W, Sun J, Tu Y, Luo W, Li C. Mediators Inflamm. 2019 Apr 3;2019:4927430. doi: 10.1155/2019/4927430. eCollection 2019.

  Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells. Chaudhary N, Ueno-Shuto K, Ono T, Ohira Y, Watanabe K, Nasu A, Fujikawa H, Nakashima R, Takahashi N, Suico MA, Kai H, Shuto T. Biol Pharm Bull. 2019 Mar 1;42(3):489-495. doi: 10.1248/bpb.b18-00928. Epub 2019 Jan 10.

  Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. Burge K, Gunasekaran A, Eckert J, Chaaban H. Int J Mol Sci. 2019 Apr 18;20(8). pii: E1912. doi: 10.3390/ijms20081912. Review.

  Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease. Gheibi S, Gouvarchin Ghaleh HE, Motlagh BM, Azarbayjani AF, Zarei L. Biomed Pharmacother. 2019 Jul;115:108938. doi: 10.1016/j.biopha.2019.108938. Epub 2019 May 6.

  Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states. Rahimi K, Ahmadi A, Hassanzadeh K, Soleimani Z, Sathyapalan T, Mohammadi A, Sahebkar A. Autoimmun Rev. 2019 Jul;18(7):738-748. doi: 10.1016/j.autrev.2019.05.012. Epub 2019 May 4. Review.

  Immunomodulatory and Anti-Inflammatory Potential of Curcumin for the Treatment of Allergic Asthma: Effects on Expression Levels of Pro-inflammatory Cytokines and Aquaporins. Shahid H, Shahzad M, Shabbir A, Saghir G. Inflammation. 2019 Dec;42(6):2037-2047. doi: 10.1007/s10753-019-01066-2.

  Curcumin as a Therapeutic Option in Retinal Diseases. López-Malo D, Villarón-Casares CA, Alarcón-Jiménez J, Miranda M, Díaz-Llopis M, Romero FJ, Villar VM.  Antioxidants (Basel). 2020 Jan 6;9(1). pii: E48. doi: 10.3390/antiox9010048. Review.

  Curcumin protects the pancreas from acute pancreatitis via the mitogen‑activated protein kinase signaling pathway. Wang Y, Bu C, Wu K, Wang R, Wang J. Mol Med Rep. 2019 Oct;20(4):3027-3034. doi: 10.3892/mmr.2019.10547. Epub 2019 Aug 1.

  Effective Medicinal Plants in the Treatment of the Cyclic Mastalgia (Breast Pain): A Review. Niazi A, Rahimi VB, Hatami H, Shirazinia R, Esmailzadeh-Dizaji R, Askari N, Askari VR. J Pharmacopuncture. 2019 Sep;22(3):131-139. doi: 10.3831/KPI.2019.22.017. Epub 2019 Sep 30. Review.

  The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases. Perrone L, Squillaro T, Napolitano F, Terracciano C, Sampaolo S, Melone MAB. Nutrients. 2019 Aug 13;11(8). pii: E1881. doi: 10.3390/nu11081881. Review.

  Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Pivari F, Mingione A, Brasacchio C, Soldati L. Nutrients. 2019 Aug 8;11(8). pii: E1837. doi: 10.3390/nu11081837. Review.

  Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases. Shimizu K, Funamoto M, Sunagawa Y, Shimizu S, Katanasaka Y, Miyazaki Y, Wada H, Hasegawa K, Morimoto T. Eur Cardiol. 2019 Jul 11;14(2):117-122. doi: 10.15420/ecr.2019.17.2. eCollection 2019 Jul. Review.

  Impact of curcumin on traumatic brain injury and involved molecular signaling pathways. Farkhondeh T, Samarghandian S, Roshanravan B, Peivasteh-Roudsari  Recent Pat Food Nutr Agric. 2019 Jun 17. doi: 0.2174/2212798410666190617161523.

  Effects of curcumin supplementation on markers of inflammation and oxidative stress among healthy overweight and obese girl adolescents: A randomized placebo-controlled clinical trial. Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M. Phytother Res. 2019 Aug;33(8):2015-2022. doi: 10.1002/ptr.6370. Epub 2019 Jun 17.

  Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial. Panahi Y, Valizadegan G, Ahamdi N, Ganjali S, Majeed M, Sahebkar A. J Cell Biochem. 2019 Sep;120(9):15989-15996. doi: 10.1002/jcb.28877. Epub 2019 Jun 6.

  Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Guerrero-Hue M, García-Caballero C, Palomino-Antolín A, Rubio-Navarro A, Vázquez-Carballo C, Herencia C, Martín-Sanchez D, Farré-Alins V, Egea J, Cannata P, Praga M, Ortiz A, Egido J, Sanz AB, Moreno JA. FASEB J. 2019 Aug;33(8):8961-8975. doi: 10.1096/fj.201900077R. Epub 2019 Apr 29.

  Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage, and Muscle Soreness. Basham SA,  aldman HS, Krings BM, Lamberth J, Smith JW, McAllister MJ. J Diet Suppl. 2019 Apr 26:1-14. doi: 10.1080/19390211.2019.1604604. [Epub ahead of print]

  Boswellia bark extract

  Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities. Efferth T, Oesch F.Semin Cancer Biol. 2020 Feb 3. pii: S1044-579X(20)30034-1. doi: 10.1016/j.semcancer.2020.01.015.

  Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts. Beghelli D, Isani G, Roncada P, Andreani G, Bistoni O, Bertocchi M, Lupidi G, Alunno A. Oxid Med Cell Longev. 2017;2017:7468064. doi: 10.1155/2017/7468064. Epub 2017 Mar 13.

  Boswellic acids: biological actions and molecular targets. Poeckel D, Werz O. Curr Med Chem. 2006;13(28):3359-69. Review.

  Boswellic acids in chronic inflammatory diseases. Ammon HP. Planta Med. 2006 Oct;72(12):1100-16. Review.

  Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M. Clin Pharmacokinet. 2011 Jun;50(6):349-69. doi: 10.2165/11586800. Review.

  The association of Boswellia resin extract and propolis derived polyphenols can improve quality of life in patients affected by prostatitis-like symptoms. Sibona M, Destefanis P, Agnello M, Lillaz B, Giuliano M, Cai T, Gontero P. Arch Ital Urol Androl. 2020 Jan 14;91(4):251-255. doi: 10.4081/aiua.2019.4.251.

  Effect Of E-OA-07 On Improving Joint Health And Mobility In Individuals With Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study. Srivastava S, Chaudhary JA, Girandola RN. J Pain Res. 2019 Dec 18;12:3365-3379. doi: 10.2147/JPR.S231237. eCollection 2019.

  Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double-blind, placebo-controlled, pilot trial. Baram SM, Karima S, Shateri S, Tafakhori A, Fotouhi A, Lima BS, Rajaei S, Mahdavi M, Tehrani HS, Aghamollaii V, Aghamiri SH, Mansouri B, Gharahje S, Kabiri S, Hosseinizadeh M, Shahamati SZ, Alborzi AT. Inflammopharmacology. 2019 Dec;27(6):1101-1112. doi: 10.1007/s10787-019-00627-z. Epub 2019 Aug 12.

  Boswellic extracts and 11-keto-ß-boswellic acids prevent type 1 and type 2 diabetes mellitus by suppressing the expression of proinflammatory cytokines. Ammon HPT. Phytomedicine. 2019 Oct;63:153002. doi:  .1016/j.phymed.2019.153002. Epub 2019 Jun 28. Review.

  Antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate gum resin in CCl4-induced hepatotoxicity. Eltahir HM, Fawzy MA, Mohamed EM, Alrehany MA, Shehata AM, Abouzied MM. Exp Ther Med. 2020 Feb;19(2):1313-1321.

  Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells. Barbarisi M, Barbarisi A, De Sena G, Armenia E, Aurilio C, Libutti M, Iaffaioli RV, Botti G, Maurea N, Quagliariello V. Phytother Res. 2019 Jun;33(6):1670-1682. doi: 10.1002/ptr.6354. Epub 2019 Mar 28.

  Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion. Ahmad S, Khan SA, Kindelin A, Mohseni T, Bhatia K, Hoda MN, Ducruet AF. Neuromolecular Med. 2019 Dec;21(4):505-516. doi: 10.1007/s12017-019-08569-z. Epub 2019 Sep 12.

  Effects of Boswellia Serrata Roxb. and Curcuma longa L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2. Governa P, Marchi M, Cocetta V, De Leo B, Saunders PTK, Catanzaro D, Miraldi E, Montopoli M, Biagi M. Pharmaceuticals (Basel). 2018 Nov 20;11(4). pii: E126. doi: 10.3390/ph11040126.

  Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia Oleo-Gum Resins. Byler KG, Setzer WN. Medicines (Basel). 2018 Aug 31;5(3). pii: E96. doi: 10.3390/medicines5030096.

  Differentially Enhancing Effects of Long-term Treatment with Serrazyme, Boswellia and Pine on Seminal Bacterial Detection in Patients with Chronic Bacterial or Inflammatory Prostatitis, Probably Related to Several Degrees of Bacterial Adherence. Vicari E, Malaguarnera G, Vicari BO, Salmeri M, Salemi M, Castiglione R. Curr Clin Pharmacol. 2018;13(3):183-189. doi: 10.2174/1574884713666180803114654.

  Novel herbal composition containing extracts of Boswellia serrata gum resin and Aegle marmelos fruit alleviates symptoms of asthma in a placebo controlled double-blind clinical study. Yugandhar P, Rao KM, Sengupta K. Phytother Res. 2018 Jan;32(1):140-150. doi: 10.1002/ptr.5963. Epub 2017 Dec 6.

  Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. Houssen ME, Ragab A, Mesbah A, El-Samanoudy AZ, Othman G, Moustafa AF, Badria FA. Clin Biochem. 2010 Jul;43(10-11):887-90. doi: 10.1016/j.clinbiochem.2010.04.061. Epub 2010 Apr 27.

  Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155. Sayed AS, Gomaa IEO, Bader M, El Sayed NSED. Mol Neurobiol. 2018 Jul;55(7):5798-5808. doi: 10.1007/s12035-017-0801-2. Epub 2017 Oct 27.

  Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes. Chilelli NC, Ragazzi E, Valentini R, Cosma C, Ferraresso S, Lapolla A, Sartore G. Nutrients. 2016 Nov 21;8(11). pii: E745.

  An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density: a randomized, double-blind study. Pasta V, Gullo G, Giuliani A, Harrath AH, Alwasel SH, Tartaglia F, Cucina A, Bizzarri M. Eur Rev Med Pharmacol Sci. 2015 Nov;19(22):4419-26.

  Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. Catanzaro D, Rancan S, Orso G, Dall’Acqua S, Brun P, Giron MC, Carrara M, Castagliuolo I, Ragazzi E, Caparrotta L, Montopoli M. PLoS One. 2015 May 8;10(5):e0125375. doi: 10.1371/journal.pone.0125375. eCollection 2015.

  Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Umar S, Umar K, Sarwar AH, Khan A, Ahmad N, Ahmad S, Katiyar CK, Husain SA, Khan HA. Phytomedicine. 2014 May 15;21(6):847-56. doi: 10.1016/j.phymed.2014.02.001. Epub 2014 Mar 22.

  Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression. Park B, Sung B, Yadav VR, Cho SG, Liu M, Aggarwal BB. Int J Cancer. 2011 Jul 1;129(1):23-33. doi: 10.1002/ijc.25966. Epub 2011 Mar 29.

  The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical trial. Khosravi Samani M, Mahmoodian H, Moghadamnia A, Poorsattar Bejeh Mir A, Chitsazan M. Daru. 2011;19(4):288-94.

  Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):653-60.

  The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation. Ranzato E, Martinotti S, Volante A, Tava A, Masini MA, Burlando B. Phytomedicine. 2017 Dec 1;36:176-182. doi: 10.1016/j.phymed.2017.09.010. Epub 2017 Sep 25.

  Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1. Verhoff M, Seitz S, Paul M, Noha SM, Jauch J, Schuster D, Werz O. J Nat Prod. 2014 Jun 27;77(6):1445-51. doi: 10.1021/np500198g. Epub 2014 May 20.